To avoid overmedication, therefore, it’s important to separate calming effects from antipsychotic effects. Choose the initial antipsychotic based on its effectiveness in treating the underlying disease, rather than relying on side effects—such as sedation—to control disease manifestations.
Rapid eye movement sleep eye movements in schizophrenia and depression. Recent meta-analyses suggest, however, that some antipsychotic effects are evident within the first week of treatment.
5-Hydroxytryptamine-2 antagonist increases human slow wave sleep.
Three case reports of modafinil use in treating sedation induced by antipsychotic medications. Sedation can occur with first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs), but it is seen more commonly and tends to be more severe with low-potency FGAs than with SGAs.
The resulting sedation can impair arousal levels during the day and increase the risk of falls.
Treatment of special populations with the atypical antipsychotics.
Collaborative Working Group on Clinical Trial Evaluations.
Effect of risperidone on sleep in schizophrenia: a comparison with haloperidol. Olanzapine acute administration in schizophrenic patients increases delta sleep and sleep efficiency.
Salin-Pascual RJ, Herrera-Estrella M, Galicia-Polo L, Laurrabaquio MR.
Efficacy of newer generation antipsychotics in the treatment of schizophrenia.
Safety and tolerability: how do newer generation ”atypical” antipsychotics compare?
Manage, don’t accept adverse ‘calming’ effect Sedation is a frequent side effect of antipsychotics, especially at relatively high doses.
Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds.
Salin-Pascual RJ, Herrera-Estrella M, Galicia-Polo L, Laurrabaquio MR. All available antipsychotics are, on average, equally effective in treating acute psychotic symptoms but vary considerably in the amount of sedation they produce. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.