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In 1812 Benjamin Rush included "Of the Morbid State of the Sexual Appetite" as chapter 18 of his book on diseases of the mind.

Most early people seem to have connected human sexuality with abundance in nature.A clay figurine of the 4th millennium BC from a temple site on the island of Malta, depicts a woman masturbating.Pan in his turn taught the habit to young shepherds.Several medical papers were written on insanity as a result of masturbation, and this was written as a reason for admission when a person was confined in a hospital.In 1743–45, the British physician Robert James published A Medicinal Dictionary, in which he described masturbation as being "productive of the most deplorable and generally incurable disorders" and stated that "there is perhaps no sin productive of so many hideous consequences".

One of the many horrified by the descriptions of malady in Onania was the notable Swiss physician Samuel-Auguste Tissot.Though Tissot's ideas are now considered conjectural at best, his treatise was presented as a scholarly, scientific work in a time when experimental physiology was practically nonexistent.The authority with which the work was subsequently treated – Tissot's arguments were even acknowledged and echoed by luminaries such as Kant and Voltaire – arguably turned the perception of masturbation in Western medicine over the next two centuries into that of a debilitating illness.The result of self-abuse in them is seen in various diseases, such as catarrh, dropsy, headache, loss of memory and sight, great weakness in the back and loins, affections of the spine, and frequently, inward decay of the head.Cancerous humor, which would lie dormant in the system their lifetime, is inflamed, and commences its eating, destructive work.The history of masturbation describes broad changes in society concerning the ethics, social attitudes, scientific study, and artistic depiction of masturbation over the history of human sexuality.